Dear Heppy
for a while now i've been looking into natural, and over the counter means of battling HCV related depression and mood swings, without having to join an ever-growing number of
antidepressant users.
my problem with ADs is, they suck all the available
serotonin from within the body and pump it into the brain. in the long term it's like running a battery completely flat, without providing any refill on the way, and after it's sucked dry - then what?
nope - i don't like that, it doesn't appeal to me, there has to be another way.
so i ventured forth on a quest and here's the result.
i found that serotonin is metabolised from
5-HTP (L-5-Hydroxytryptophan) - i got excited, it seemed like i had found the solution fairly quickly, but with more in depth reading, obstacles have started to mount.
in itself 5-HTP crosses the blood-brain barrier very easily, but when administered orally as a supplement, it is readily converted into serotonin while still in the blood stream, and serotonin molecule is too big to get to the brain where it's required. especially, if someone like me, infected with you, Dear Heppy, is taking vit B6, which facilitates that conversion.
dang! so now what?
well there is a
way of stopping 5-HTP from converting into serotonin, before it reaches the brain, with a drug called
carbidopa - awesome? erhm not as much as it seems again, for carbidopa carries its own set of possible side effects, and in overall there is no consensus, whether it's better to take 5-HTP with or without it.
uuugh i'm getting confused and frustrated!
this neat
fact sheet could ease my mind, but it's based on research and studies dating back from '90s and its authors seem too eager with promoting 5-HTP without single mention of any drawbacks - hmmm.
still, i wasn't giving up that easily.
i took another step back in the chemical process and dug fiercely into
L-tryptophan, immediate precursor to 5-HTP.
future looked bright again, as i read more about
benefits of this fantastic essential amino acid. not only it is good for depression, but also for insomnia, food cravings and aging - yes, tryptophan stimulates production of
HGH (human growth hormone) - too good to be true?
indeed...
tryptophan requires vit B3 to metabolise into 5-HTP, it has to compete with other amino acids for a lift to the brain (that's why it should be taken away from food and with quick releasing carbohydrates ie fruit juice), plus a significant amount is catabolised into other various by-products including
kynurenine and
quinolinic acid which are neurotoxic, so it's not exclusively converted into 5-HTP only - whatta bummer.
nevertheless
research supports that either, L-tryptophan or 5-HTP, are better solution to depression, rather than conventional ADs.
even more so, in case of HCV infection and especially tx, it's been
proven that plasma level of tryptophan drops dramatically in presence of INF-α during the treatment resulting in irritability, mood swings and depression.
this
small study presents that supplementing with tryptophan during tx for HCV can alleviate severity of depression. and it has been later followed up by
discussion in favour of 5-HTP.
despite certain drawbacks to use of either L-tryptophan or 5-HTP, there is no question, as to how hugely beneficial they can be, for anyone who suffers from HCV related depression or even more so, when undergoing grueling tx for hepC.
in the end, my dilemma only boils down to the choice - which one should i pick to treat myself with?
i think, i shall experiment with tryptophan first, and if it doesn't take me on a trip-to-fun, then i would switch to 5-HTP.
it's just ironic, that in ireland, being a country with high prevalence of depression and suicide rate, both are forbidden and unavailable.
thank god for the internet and online shopping!
but please Dear Heppy shhhh! don't tell anyone ok?
me
